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Registration Information
Registration Information
Name of the cell
Has the CL been derived with the Donors´ Informed Consent?
---
Yes
No
Applicable Legislation
-
EU regulations
NIH Regulations
Government of India regulations
HEF Act
National
Natioanal
Natioanl
Institutional review board approval
French Bioethics Law
National Legislation
EC Directive 90/219/EEC
HFEA regulations
Federal Commission for Medical and Scientific Research on embryos (Belgium)
Harvard institutional review board
Spanish Bioethics law
National guidelines
Ethical comitee Institute of Experimental Medicine,Academy of Science,Czech Republic
Is the donor traceable?
---
Yes
No
Applicable Legislation
-
EU regulations
NIH Regulations
Government of India regulations
HEF Act
National
Natioanal
Natioanl
Institutional review board approval
French Bioethics Law
National Legislation
EC Directive 90/219/EEC
HFEA regulations
Federal Commission for Medical and Scientific Research on embryos (Belgium)
Harvard institutional review board
Spanish Bioethics law
National guidelines
Ethical comitee Institute of Experimental Medicine,Academy of Science,Czech Republic
Derivation Data
Origin
---
Embryo
iPS cells
Source
---
IVF
SCNT
Parthenogenesis
IVF
-
supernumary IVF embryo
IVF solely for research
PGD Embryo
---
Yes
No
Diagnosis
monogenetic disease
chromosomal abnormalities
HLA typing
Oocytes
---
Human
Other
Specify Species
Sex
-
Female
Male
Single cell derivation
---
Yes
No
Primary Cell Type
-
Human Fibroblasts
spermatogonial cells
human foreskin keratinocytes
Epidermal keratinocytes
Amniocytes
Induced Genes
-
None
OCT4, Sox2, KLF4, c-Myc
OCT4, Sox2, KLF4
Oct4, Sox2, Lin28, Nanog
Oct4, Sox2
Transformation Method Used
-
None
Inherent
Induced
Lentivirus
Retrovirus
Specifiy embryo stage
-
16 days
16 days
4 cell stage
blastocyst
8-10 cells
6-8 Cells
Availability
Cell line available
-
Yes
No
Karyotyping
Karyotype
-
46XX
46XY
47XX,+13
47XX,+17
63XXX
46XX,inv9
46, XX, +5q14.2-q35.3, -18q21.2-q23
61XX
69XXY
Mosaic 69XXY
-
46, XX, +1, -21
49 XXY
46XX, -13, +17
69, XXX
46XX,+15,-17
49XXy,+12+17
49XXY,+12,+17
46, XX, dup(7)(q33qter), del(18)(q23qter)
47XXY
24 of 30 cells=46XY. 1 cell=92XXYY, 1 cell=45Y-?X, 1 cell=42Y-1, 3 cells had rings and fragments.
47XX,+16
46XX,i(13)q(10)/46XX
47XY,+5
46XXDER T(4;13)
transloc
47XX,+14
47XXX
47XY,+12
46XX,+16
47XX,+20
46XX and 48XX+12+17
46XX i(20)q
46XX,+13,der(13;13)(q10;q10)
45, XO
46XY+16
68,XXY,-6
46,XX,der(7)t(7;12)(q31.1;p13.1)pat
47,XX,+12,del(18)(q21.2q21.3)
47,XX,+17,del(18)(q21.2q21.3)
46,XX,del(18)(q21.1q21.3)
46,XX,der(9)t(1;9)(q21;p2),der(15)t(15;17)(p11;q11.2)
46,XX,der(8)t(8;17)(p11.2;q11),del(18)(q21.2q21)[5]/46,XX,del(18)(q21.2q21.3)[10]
46,XX der.(10)t(7,10)(p 14;p 12]
47 (13), i
46 (del)
46,XYt(1;21) (ptel;qtel)
47XX +13 and i
46,XY,der(21)t(1;21)(p36;q22).ish der(21)(21qter-,1pter+).arr1p36.32p36.33(985,153-4,637,952)x3.arr21q22.3(43,659,526-49,928,776)x1
46,XX.arr(1-22,X)x2
46,XY,t(8;9)(p23;p24).ish t(8;9)(8pter-,9pter+,8qter+;9pter-,8pter+,9qter+)
47XY, +21
translocation
45, XX, der(13;14)(q10;q10)
46, XX / Familial Hypercholesterolemia
46, XY / Glycogen Storage
46, XX / Tyrosinemia
46, XX / Heridatory Cholestasis
46, XY, per inv(9)(p11q12) / Retinitis Pigmentosa
46, XY / Leber's Congenital Amaurosis
46, XX / Usher syndrome
46, XX / Retinitis Pigmentosa
46, XX / Age Related Macular Degeneration
46, XY / Leber’s Hereditary Optic Neuropathy
46, XX / Cligler Najjar
46, XY / Cligler Najjar
Highest Passage No. for above Karyotype
Karyotype Change
---
Yes
No
Karyotype
-
46XX
46XY
47XX,+13
47XX,+17
63XXX
46XX,inv9
46, XX, +5q14.2-q35.3, -18q21.2-q23
61XX
69XXY
Mosaic 69XXY
-
46, XX, +1, -21
49 XXY
46XX, -13, +17
69, XXX
46XX,+15,-17
49XXy,+12+17
49XXY,+12,+17
46, XX, dup(7)(q33qter), del(18)(q23qter)
47XXY
24 of 30 cells=46XY. 1 cell=92XXYY, 1 cell=45Y-?X, 1 cell=42Y-1, 3 cells had rings and fragments.
47XX,+16
46XX,i(13)q(10)/46XX
47XY,+5
46XXDER T(4;13)
transloc
47XX,+14
47XXX
47XY,+12
46XX,+16
47XX,+20
46XX and 48XX+12+17
46XX i(20)q
46XX,+13,der(13;13)(q10;q10)
45, XO
46XY+16
68,XXY,-6
46,XX,der(7)t(7;12)(q31.1;p13.1)pat
47,XX,+12,del(18)(q21.2q21.3)
47,XX,+17,del(18)(q21.2q21.3)
46,XX,del(18)(q21.1q21.3)
46,XX,der(9)t(1;9)(q21;p2),der(15)t(15;17)(p11;q11.2)
46,XX,der(8)t(8;17)(p11.2;q11),del(18)(q21.2q21)[5]/46,XX,del(18)(q21.2q21.3)[10]
46,XX der.(10)t(7,10)(p 14;p 12]
47 (13), i
46 (del)
46,XYt(1;21) (ptel;qtel)
47XX +13 and i
46,XY,der(21)t(1;21)(p36;q22).ish der(21)(21qter-,1pter+).arr1p36.32p36.33(985,153-4,637,952)x3.arr21q22.3(43,659,526-49,928,776)x1
46,XX.arr(1-22,X)x2
46,XY,t(8;9)(p23;p24).ish t(8;9)(8pter-,9pter+,8qter+;9pter-,8pter+,9qter+)
47XY, +21
translocation
45, XX, der(13;14)(q10;q10)
46, XX / Familial Hypercholesterolemia
46, XY / Glycogen Storage
46, XX / Tyrosinemia
46, XX / Heridatory Cholestasis
46, XY, per inv(9)(p11q12) / Retinitis Pigmentosa
46, XY / Leber's Congenital Amaurosis
46, XX / Usher syndrome
46, XX / Retinitis Pigmentosa
46, XX / Age Related Macular Degeneration
46, XY / Leber’s Hereditary Optic Neuropathy
46, XX / Cligler Najjar
46, XY / Cligler Najjar
Highest Passage No. for above Karyotype
Genetic Manipulation/Mutation
Occurrence
---
None
Inherent
Induced
Lentivirus
Retrovirus
Cell Line Morphology
---
colonies
undifferentiated uniform hES colonies
None
differentiation from edges of colonies
undifferentiated colonies
uniformly undifferentiated hESC colonies
Undifferentiated cells cultured as colonies
Undifferentiated cells cultured as colonies or as singles cells
Genetic Disorder
Female, Fragile-X Syndrome, carrier (> 500 repeats)
Fanconi Anemia-A, 14 bp deletion, carrier
Neurofibromatosis, Type I affected
Myotonic Dystrophy affected
Beta globin mutation IVS 110, carrier
Beta-Thalassemia affected
Becker Muscular Dystrophy affected
Duchenne Muscular Dystrophy, carrier
Adrenoleukodystrophy (ALD, X-linked) affected
Male, Fragile-X Syndrome, affected
Emery Dreifius Muscular Distrophy X-link, carrier (XXY)
Cystic Fibrosis
Aneuploidy
Hemophilia A
Homologous Recombination
FSHD (Facioscapulohumeral Muscular Dystrophy)
SCA7 (Spinocerebellar Ataxia Type 7)
Fragile X Syndrome
X-linked Disease
Triploid karyotype
Charcot-Marie Tooth type 1A
Osteogenesis Imperfecta Type 1
Huntington Disease and Marfan Syndrom
Myotonic Dystrophy Type 1(DM1) Expansion of >150 CTG repeats in DMPK gene
STR-233-FRAXA
Fabry Syndrome
Huntington disease
MULTIPLE ENDOCRINE NEOPLASIA, TYPE IIA
Spinocerebellar ataxia type 2
MYOTUBULAR MYOPATHY X linked
Marfan Syndrome
ADENOMATOUS POLYPOSIS OF THE COLON
Multiple exostosis type2
None
Balanced translocation
Down syndrom
Myotonic Dystrophy type 1(DM1)
myotonic dystrophy type 1
Von Hippel Lindau
Gene Knock-out
FANCD2
Transgene
hOct4-GFP
GFP
Reporter gene
-
EGFP , RFP-H2B
EmGFP
GFP
Differentiation into cell types of the 3 germ layers
In vitro
Ectoderm
---
Yes
No
Method
Spontaneous
Embryoid Bodies
Directed
Mesoderm
---
Yes
No
Method
Spontaneous
Embryoid Bodies
Directed
Endoderm
---
Yes
No
Method
Spontaneous
Embryoid Bodies
Directed
In vivo
Ectoderm
---
Yes
No
Differentiation
Teratomas
Chimeras
Mesoderm
---
Yes
No
Differentiation
Teratomas
Chimeras
Endoderm
---
Yes
No
Differentiation
Teratomas
Chimeras
Cell Marker
ALPL activity assay
+
-
±
ALPL
+
-
±
CD9
+
-
±
DNMT3B
+
-
±
GABRB3
+
-
±
GCTM2
+
-
±
GCT343
+
-
±
GDF3
+
-
±
NANOG
+
-
±
POU5F1 (OCT-4)
+
-
±
SSEA-3
+
-
±
SSEA-4
+
-
±
TRA 1-60
+
-
±
TRA 1-81
+
-
±
TDGF1
+
-
±
THY1 (CD90)
+
-
±
REX-1
+
-
±
SSEA-1
+
-
±
SOX-2
+
-
±
Additional Information
Additional Information
Was there a specific purpose to derive the CL?
---
Yes
No
Has the CL been derived under GMP?
-
Yes
No
HLA Typing
Type I
A
allele 1:
allele 2:
B
allele 1:
allele 2:
C
allele 1:
allele 2:
Type II
DR
allele 1:
allele 2:
DQ
allele 1:
allele 2:
DP
allele 1:
allele 2:
Virology/Microbiology Screening of Donors
HIV I
Result
+
-
±
from:
-
-
to:
-
-
HIV II
Result
+
-
±
from:
-
-
to:
-
-
HBV
Result
+
-
±
from:
-
-
to:
-
-
HCV
Result
+
-
±
from:
-
-
to:
-
-
TPHA
Result
+
-
±
from:
-
-
to:
-
-
Additional derivation data
Date of embryo generation
from:
-
-
to:
-
-
Embryo stage
-
Early cleavage
Morula
Blastocyst
Other
Embryo quality
-
Good
Intermediate
Poor
Blastocyst quality
Expansion status
-
1
2
3
4
5
6
ICM morphology
-
A
B
C
D
E
Trophectoderm morphology
-
A
B
C
Cell line derivation
Date of derivation of cell line
from:
-
-
to:
-
-
ZP removal
-
Spontaneous hatching
Enzymatic
Chemical
Mechanical
Cell isolation
-
Immunosurgery
Mechanical
Laser
None
Seeding
-
Embryo
Isolated ICM
Single cell
Cell line culture conditions
Culture medium
-
DMEM F/12
DMEM/F-12
Knockout-DMEM
High glucose DMEM
VItrohes
DMEM/F12 with Glutamax
DMEM
TeSR1
X-VIVO10
RegES
KOSR-XF
Protein source
-
Serum free
Foetal bovine serum
Foetal calf serum
Serum Replacment
Knockout-Serum Replecement
Serum Replacement
Knockout-Serum Replacement
human serum
Fetal Bovine Serum
Anti-Human-Serum(Sigma)
Serum concentration (percentage)
Surface Coating/Matrix
-
MEF
hFF
Cultured on Conditioned Medium harvested from a culture of NCL-1 hESC grown on Mitotically Inactivated MF-1 MEFs
Gelatin
Human dermal fibroblast
Human lung fibroblasts
Human foreskin fibroblasts
Matrigel
PMEF
human uterine endometrial cells (hUECs)
Cellstart
Supplements
-
L-Glutamine
Medium conditioned by hES-NCL1 cells
glutamax
Bovine Serum Albumin(BSA)
Fetal Calf Serum
Human Serum Albumin
2-mercaptoetanol
2 mM L-glutamine , 0.1 mM β-mercaptoethanol, 1% nonessential amino acids, 100 units/ml penicillin and 100 µg/ml streptomycin and insulin-transferrin-selenite
Growth Factor Cocktail
Growth factors
-
FGF 2
hrbFGF
bFGF
LIF
bFGF,GABA,LiCl
bFGF + LIF
bGFG + LIF
Freeze/thaw method
-
Vitrification in pulled ofen straws and slow freezing for larger quantiities
freeze/thaw
Vitrification in pulled ofen straws followed by rapid freezing in liquid N2
Vitrification in pulled open straws followed by rapid freezing in liquid N2
FCS/DMSO slow freezing procedure
Vitrification by open pulled straw technique
vitrification
FBS+DMSO (10%)
RBM Online Vol 17, Nº1, 2008, 127-135
Vol 17 No 1. 2008 127-135 Reproductive BioMedicine Online; www.rbmonline.com/Article/3217 on web 16 May 2008
vitrification in completely sealed straws
FBS/DMSO slow freezing procedure
Vertification closed with Straws 20%DMSO
-
HEPES&DMSO 20%
Vitrification in completely closed vials
50% KOSR +10% DMSO
20%KSR + 10%DMSO + Rock Inhibitor
20%KSR + 10 DMSO + Rock Inh.
20%KSR / 10%DMSO / Rock Inh.
Gas phase O
2
(percentage)
Gas phase CO
2
(percentage)
Passaging Method
Enzymatic
Mechanical
Enzyme(s) used
trypsine
mechanical
Collagenase
Feeder cells
Cell name or strain of origin
-
NEW
CF-1 mice
CRL-2429;ATCC, Manassas, VA
human foreskin fibroblats
Swiss MF-1 Mice
ICR
MF-1 and CF-1 (passage 4)
B-81 MEF
PMEF-N
CEF23b
CD-1
HS27
HDFn
HFL-1
human foreskin fibroblasts
STO
SCRC-1045.2
BALb/c mice
CFLP-mice
C57BL/6
primary mouse embryonic fibroblasts (PMEFs)
PMEF
NMRI
MEF/ SL10
MEF
NMRI outbred strain mice
Original tissue type
-
12,5day embryos
Human Foreskin
mouse embryo fibroblast
Human dermal fibroblasts
Human foetal lung
Term human placenta
E13.5 p.c
Human Fetal Fibroblasts
placental fibroblast (PLFb)
Human Embryonic Fibroblasts (HEFs)
EDFs
Seeding density (x 10
6
cells per ml)
Maximum passage for use
Feeder cell inactivation
-
Mitomycin C
Irradiation
Matrix used
---
None
Protein
Synthetic
Other
Protein(s) used
gelataine
gelatin
gelatine
Type A gelatin from porcin skin
Material(s) used
Gelatine
Teratoma information
Strain of mice
-
SCID BEIGE mice
NOD SCID mice
nude mice
CB-17SCID
C.B-17/IcrCrl-scidBR
SCID
NOD/MrkBomTac-Prkdcscid
Age of mice (months)
Passage at inoculation
Inoculation site
-
gastronemic muscle
Testis
Rear leg muscle
Subcutaneous
kidney capsule
Testis Capsule
Subcutaneous, dorsal flank
Subcutaneous into the hind leg
intramuscular
subcutaneous into the back
into the calf muscles
right hind limb
into hind leg muscles
into thw thigh muscles
into the thigh muscles
Inoculum preparation
-
clumps of cells resuspended amb hES medium
Single cells resuspended in hESC medium
clumps of cells suspended in Matrigel + media
clumps of cells resuspended in hES
clumps of cells resuspended in hES medium
clumps of cells resuspended in hES medium
clumps of cells resuspended in PBS
colonies mechanically cut or trypsinized and resuspended in PBS
1. ES cells were cultured as colonies on MEF feeder layers and were passaged manually by dissection (see Appendix 3).
20 colony pieces (mechanically dissected) were transferred through two 200 μl drops of PBS to rinse and were then suspended in 20 μl PBS per 20 pieces. 20 pieces were injected under the kidney capsule of each SCID mouse.
into hind leg muscle
clumps of cells in matrigel 1:2 diln
clumps of sell resuspendet in PBS + Matrigel
clumps resuspemded in PBS and Matrigel
clump of cells resuspended in PBS and Matrigel
Number of cells injected
Type of histology
-
immunohystoquemistry/ traditional histology
HE
immunohystochemistry/traditional histology
immunohistochemistry/traditional histology
cryosection H&E and immunostaining
no teratoma seen
immunhistochemistry HE
immunohistochemistry
Chimeras
Animal species
-
Mouse
Rat
Goat
Sheep
Strain of recipient
-
Age of recipient
Passage at injection
Number of cells injected
Percentage of integrated cells
Site of integration
-
Liver
Developmental time point
-
E0
E1
E21
Regulatory documents
MTA
---
Yes
No
Copy of blank consent form
---
Yes
No
Institutional review board approval/Competent authority approval
-
Regional ethical committee in Gothenburg, Sweden
Regional ethical committee
Ethics Board of the Center of Regenerative Medicine in Barcelona
Institutional Commitee for Stem Cell Reseaarch and Therapy (IC-SCRT)
Local Institutional Review Board
National
Local ehical and national legal authorization
Federal Commission Medical and Scientific Research on embryos in vitro (Belgium)
Federal Commission for Medical and Scientific Research on embryos in vitro
Ethics Cimmittee of Sun Yat-sen University
Ethics board of the Prince Felipe Research Centre
Ethical Comitee Institute of Experimental Medicine, Academy of Science,Czech Republic
Institutional review board for stem cell research
Agence de la Biomédecine (France)
Ministry of Education,Youth and Sports
NRES
Are there references or weblinks for SOPs?
---
Yes
No
Weblink
Official oversight bodies involved
-
Yes
No
Are there specific measures employed to establish traceability?
---
Yes
No
Is there a certificate of analysis available?
---
Yes
No
Accrediting authority involved
-
Instituto Salud Carlos III
HFEA
Agence de la biomédecine
Ministry o Education, Youth and Sports
Federal Office of Public Health (OFSP)
Regional ethics board, Stockholm
Ethics committee for stem cell research of Ministry of Education, Culture, Sports, Science and Technology (MEXT)
Ruijin Hostpital in Shanghai, China
Regional ethics board, Tampere, Finland
no accrediting authority involved
Education,Youth and Sports
Clinical Application
Cell line used in pre-clinical studies?
---
Yes
No
For which indication?
Cancer
Accrediting authority for clinical application
-
Cell line used in clinical studies?
---
Yes
No
For which indication?
Cancer
Accrediting authority for clinical application
-
Publications and Projects
Publications and Projects
Project
Title
Abstract
Publication
Title
Source
PMID
DOI
Abstract
Working Group
Working Group
Category
-
COM
RES
GOV
BANK
Institution
-
Masaryk University
Charité Universitätsmedizin Berlin
University of Newcastle
National Institute for Biological Standards and Control
Cellartis AB Sweden
Instituto de Salud Carlos III
Centre of Regenerative Medicine in Barcelona
Vrije Universiteit Brussel
Hadassah University Hospital
Netherlands Institute for Developmental Biology
University of Pittsburgh
University of Helsinki
University of Copenhagen
Geneva University
Scottish Stem Cell Network
International Hospital Istanbul
King's College
Agence de la Biomedicine
University of Edinburgh
Karolinska Institutet
INSERM
INSERM Rhône-Alpes Auvergne
Banco Andaluz de Células Madre
Principe Felipe Centro de Investigacion
University of Sheffield
Axordia Ltd.
Technion - Israel Institute of Technology
Martin-Luther-Universität Halle-Wittenberg
Universitat de Barcelona
European Commission
ESHRE
Ciconia Aarhus Privathospital
University of Southern Denmark
University of California, San Francisco
University of Tampere
Sydney IVF Limited
University of Wisconsin - Madison
Hebrew University of Jerusalem
University of Nottingham
Roslin Institute
Harvard University
Prince of Wales Hospital
Advanced Cell Technology, Inc.
University of Cambridge
Stem Cell Sciences plc
WiCell Research Institute
Novocell, Inc.
ES Cell International Pte Ltd.
Kyoto University
Mount Sinai Hospital
Université Libre de Bruxelles
Juvenile Diabetes Research Foundation (JDRF)
Lund University
Novo Nordisc A/S
AbCys
Memorail Hospital ART&Reproductive Genetics Center
University of Milan
ISTANBUL MEMORIAL HOSPITAL
University of Tuebingen
Jawaharlal Nehru Centre for Advanced Scientific Research
University Hospital of Montpellier
University of Amsterdam
University of York
IRCCS
Monash University
IVF Australia
Leiden University Medical Center
Lisbon University
Children's Hospital
Aalborg University
Russian Academy of Sciences
University College London
Royan Institute
Maria Infertility Hospital
Tata Institute of Fundamental Research
MizMedi Hospital
Université Paris-Sud 11
Invitrogen Corporation
Charité - Universitätsmedizin Berlin
Institut Pasteur
Roslin Cells Ltd.
Vavilov Institute of General Genetics Russian Academy of Sciences
Ruprecht-Karls-Universität Heidelberg
CNRS
University of Manchester
Central Manchester and Manchester Children\'s University Hospitals NHS Trust
Stanford University School of Medicine
Sun Yat-sen University
Central Manchester and Manchester Children's University Hospitals NHS
Eastern Virginia Medical School
Central South University
Pochon CHA University College of Medicine
The Salk Institute for Biologiecal Studies
Shanghei Second Medical University
Seoul National University
Reproductive Genetics Institute
Kaohsiung Medical University
The Rockefeller University
Singapore Stem Cell Consortium
National Taiwan University
Peking University Third Hospital
Dhirubhai Ambani Life Sciences Center
Shanghai Jiao Tong University School of Medicine
National Institute for Research in Reproductive Health
Civil Hospital Campus
The Salk Institute for Biological Studies
Graduate University of Chinese Academy of Sciences
Sun Yat-sen University Second Affiliated Hospital
Huazhong University of Science and Technology
xxxx
University of Basel
The Third Affiliated Hospital of Guangzhou Medical College
MABIO
Université de Strasbourg
CABIMER (Centro Andaluz de Biología Molecular y Medicina Regenerativa - Andalusian Molecular Biology and Regenerative Medicine Centre)
Sunvim Bioscience
Faculty/Business Unit
-
Faculty of Medicine
CharitéCentrum 12 für Innere Medizin und Dermatologie
Faculty of Medical Sciences
UK Stem Cell Bank
Subdirección General de Investigación en Terapia Celular y Medicina Regenerativa
Centre for Medical Genetics
Stem Cell Research Center
McGowan Institute for Regenerative Medicine
Biomedicum Stem Cell Center
Juliane Marie Center for Women, Children and Reproduction
Pole Recherche
Centre for Regenerative Medicine
Karolinska University Hospital
Unit 846
Berlin-Brandenburg Centre for Regenerative Therapies
Faculty of Pure Science
The Ruth and Bruce Rappaport Faculty of Medicine
Theologische Fakultät
Directorate-General Research
Faculté de Médecine
Fertility Clinic
Faculty of Health Science
School of Biomedical and Health Sciences
UCSF Medical Center
School of Medicine and Public Health
Karolinska Institutet
The Alexander Silberman Inst. of Life Sciences
Faculty of Medicine and Health Sciences
School of the Biological Sciences
Surgical Clinic
Institute for Frontier Medical Sciences
Samuel Lunenfeld Research Institute
sadad
Diabetes Research Centre
Department of Experimental Medical Science
Hagedorn Research Institute
Centre for STem Cell Research
Institute of Pharmacology und Toxicology
Stem Cell Laboratory
Institute for Research in Biotherapy
Academic Medical Center
Centro Trasfusionale e di Immunologia dei Trapianti
Institut Pasteur
R&D Laboratory
Faculty of Medicine, Nursing and Health Sciences
Administration
Howard Hughes Medical Institute
Branch of Physical Chemstry Biology
Faculty of Biomedical Sciences
National Center fer Biological Sciences
Corporate Headquarters
Wissenschaftlich-Theologisches Seminar
Faculty of Pure Sciences
University Hospitals and the School of Medicine
University Paris Diderot
NWESCC
St Mary\'s Hospital
Institute for Stem Cell Biology & Regenerative Medicine
First Affiliated Hospital
St. Mary's Hospital
Institute of Human Reproductive and Stem Cell Engineering
College of Medicine
Cell and Gene Therapy Research Institute
Institute of Zoology
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Tongji Medicne College
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Stem Cell and Brain Research Institute
Institut de génétique et de Biologie Moléculaire et Cellulaire
UEVE
Institut de Génétique et de Biologie Moléculaire et Cellulaire
Women's Hospital
Molecular Biology and Regenerative Medicine Centre
Department
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Department of Biology
Institute für medizinische Immunologie
Institute of Human Genetics
Hubrecht Laboratory
Department of Surgery
Dept. of Clinical Science, Intervention and Technology
Stem Cell and Brain Research Institute
CellNet.org
Department of Biomedical Science
Department of Obstetrics and Gynecology
Institut für Systematische Theologie
DG XII-B1-3 SDME 7/15
Hôpital Erasme
Wolfson Centre for Age Related Diseases (CARD)
Department of Obstetrics, Gynecology and Reproductive Sciences
Regea Institute for Regenerative Medicine
Genome Center of Wisconsin
Deptartment of Genetics
Centre for Biomolecular Sciences
Division of Gene Function and Development
Department of Molecular Cell Biology
Diabetis Transplant Unit (DTU)
Wellcome Trust Centre for Stem Cell Research
SC Services
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Stem Cell Research Center
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JDRF Center for Beta Cell Therapy in Diabetes
Stem Cell Center
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Gene Therapy Institute
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ASSISTED REPRODUCTIVE TECHNIQUES AND REPRODUCTIVE GENETICS
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Molecular and Cancer Biology Research Program
Molecular Biology and Genetics Unit
Stem Cell Laboratory
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ART&Reproductive Genetics
Monash Immunology & Stem Cell Laboratories
Dept. Anantomy & Embryology
Institute of Molecular Medicine
Department of Hematology/Oncology
Department of Health Science and Technology
Institute of Gene Biology
Institute of Child Health
Department of Stem Cells
Medical Institute
Neurobiology
André Lwoff Institute
Corporate Headquarters
Department of Neuroscience
Lund Stem Cell Center
Lehrstuhl Systematische Theologie/Ethik
Department of Tissue Engineering at the Anatomical Institute
Lamarck Building
FLS
Department of Reproductive Medicine
Department of Thoracic Surgery
Department of Cell and Tissue Biology
Department of Biotechnology
Stem Cell Biology
Department of Nephrology and Transplantation Medicine
Neurologic Department and Reproductive Medicine Center
cell biology
Guangzhou Key Laboratory of Reproductive and Genetics
Departmant of Cell Biology and Development
Département de Biologie Cellulaire et Développement
Gynecological Endocrinology and Reproductive Medicine
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